Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial

Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily. Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54&plusmn;0.83) compared to the control group (2.39&plusmn;0.88) (P<0.001) and a significant increase in GCS value (14.46&plusmn;0.88) compared to the control group (12.86&plusmn;1.78) (P<0.001).&nbsp; Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07&plusmn;34.80, control group: 51.75&plusmn;42.10, P=0.98) and CRP (Septimeb group: 48.86&plusmn;23.21, control group: 49.93&plusmn;36.22, P=0.92) decreased, but did not show a significant reduction. Conclusion: Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients&rsquo; mortality rates.